Greenville was founded in 1815 by George Davidson-three years before Illinois became a state. Greenville became the seat of government for Bond County in 1821. 

The Greenville Chamber of Commerce is organized to advance the general welfare and prosperity of the Greenville area so that its citizens and all areas of its business community shall prosper. All necessary means of promotion shall be provided and particular attention and emphasis shall be given to the economic, civic, commercial, cultural, industrial and education interests of the area.