The Lewis Cass Intermediate School District (ISD) is incorporated in the state of Michigan. ISDs function as regional service centers to provide special education, instructional services, and career technical education coordination for local school districts.

Lewis Cass ISD currently employs more than 175 persons. Its geographic coverage encompasses approximately 487 square miles and includes most of Cass County and small portions of Berrien, St. Joseph and Van Buren counties in lower southwest Michigan. Four local school districts: Cassopolis, Dowagiac, Edwardsburg, and Marcellus, as well as the county's private and parochial schools depend on the Lewis Cass ISD for the provision and coordination of general and specialized services.