Main Street Baptist Church (MSBC) is a Southern Baptist church located just off the University of the Cumberlands campus in Williamsburg Kentucky. MSBC celebrated 100 years of ministry in June of 2006, and moved into their new worship and activities center the following spring.

MSBC is affiliated with the Southern Baptist Convention, Kentucky Baptist Convention and the South Union/Mount Zion Baptist Assocation and supports evangelism through local outreach, and the North American and International Missions Board.