San Luis is referred to by anthropologists as "a distinct socio-cultural era of exceptional interest". The town was founded in 1851 and was once a part of four Spanish Land Grants decreed by the King of Spain. Here you will find the "vega", one of the two remaining "commons" in the United States, the oldest water rights in Colorado, and the oldest family store in the state.

The Museum features murals and works of art from its own collection and on loan from various artists and collectors, many of whom are local residents. The Gift Shop offers paintings and other art objects by various local artists.

The north wing of the complex houses the Carlos Beaubien Theatre, which shows movies on summer weekends and in the past has been used to host the Santa Ana / Santiago Queen Pageant. The theatre has also been the setting of several stage performances, presentations, and concerts. Because much of the original decor has been maintained throughout the building, the original vigas and fireplace still grace the theatre.