Located in the BBQ Capitol of Illinois you will enjoy nationally acclaimed 17th Street BBQ®. Holiday Inn Express & Suites® Murphysboro-Carbondale Hotel is nestled within a growing development at the intersection of Walnut St & N 2nd St just twenty-one miles west of highway 57 with access to everything southern Illinois has to offer. The hotel is just 8 miles directly west of Southern Illinois University Carbondale, home of the Salukis. Business travelers will benefit from our central location with easy access to highway 13 that offers access to areas of southern Illinois within minutes. The hotel is just minutes from St Joseph Memorial Hospital, Penn Aluminum International, and Com-Pac International. Our nonsmoking Holiday Inn Express & Suites® Murphysboro-Carbondale hotel is convenient to guests visiting Southern Illinois University Carbondale, Shawnee National Forest, Kinkaid Lake, Lake Murphysboro State Park, Science Center Southern Illinois, Crab Orchard Lake, Shawnee Hills Wine Trail and much more! Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Meeting Room, Complimentary Express Start Breakfast, Complimentary IHG Connect High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly. Enjoy our Midwest hospitality in Murphysboro. Our goal is to make every guest feel at home so that we exceed all of their expectations!