The Greene County Fairgrounds is believed to be the only fairgrounds owned by a county entity in the State of Pennsylvania. Most others are owned by shareholders. The present site contains 26-acres of land and is located between Route 21 (Roy Furman Highway) and Route 188 (Jefferson Road) in Waynesburg, Pennsylvania. There are three (3) entrances to the grounds; one off of Route 188, one on the eastern side and one on the western side of the grounds off of Route 21. The initial fairground site was originally located on what is now the Waynesburg College Football Field.

The initial fair was held about 1867 in Waynesburg and was sponsored by the Waynesburg Central Fair Association. It took place on the fairgrounds, which was then located on the south side of Waynesburg, east of Morgan Street (in the area where the current Waynesburg College football field).