The Isabel Anderson Comer Museum and Arts Center houses a permanent art collection as well as Indian artifacts and Civil War and World War II memorabilia. Exhibits dedicated to local notable figures include Jim Nabors, who played Gomer Pyle on the Andy Griffith Show and Bill Nichols, former U.S. Congressman, among others

The museum was opened in 1982 and is named for its founder, Mrs. Isabel Anderson Comer, who conceived the idea in 1977.After several years of meetings, planning, and negotiations, the museum opened its doors in 1982. Prior to becoming a museum, the building was a public library. The dark area on the floor in the foyer shows the location of the check-out desk. It was Mrs. Comer's inspiration and untiring efforts, along with help from many other Sylacaugans, that brought the metamorphosis from a library to a museum.