The DeSoto Center campus, financed through the efforts of the taxpayers of DeSoto County, is a 94,000-square-foot structure situated on a beautiful 47-acre site in Southaven, Mississippi. This site, donated by the W.E. Ross family, offers the college opportunities to expand as DeSoto County continues to grow.

The architectural design of the two-and-one-half-story, steel frame facility with a standing seam metal roof is post-modern with early Wrightian influences. Designed to accommodate 1,406 people, the building contains 28 classrooms, four computer labs, two science labs, one practical nursing lab, and 39 offices. The focal point of the DeSoto Center campus is a glass and steel tower that forms the atrium/commons. A closed-circuit TV system provides security for the building as well as the parking area, which has a capacity for approximately 800 cars.

In an effort to meet the training needs of the citizens of DeSoto County and surrounding areas, a career-technical campus was established in the Olive Branch Metro Industrial Park. The campus officially opened in the fall of 1985. DeSoto Center-Olive Branch offers an Aviation Maintenance Technology degree program and a Commercial Truck Driving course.