The Trinidad State Junior College Valley Campus is located in the San Luis Valley, which consists of six counties: Alamosa, Conejos, Costilla, Mineral, Rio Grande, and Saguache. Located in a broad, mostly flat valley, as much as 100 miles long and 75 miles wide, with an elevation of 7,500 feet at the Valley floor, the region is rimmed by high mountains to the north, east, and west, with elevations up to 14,345 feet. The Rio Grande River rises in the western part of the region and flows south into New Mexico. The region has an area of 8,180 square miles and a population of approximately forty thousand people. Major communities in the Valley include Alamosa, Monte Vista, Del Norte, Center, Antonito, Manassa, San Luis, La Jara, Sanford, Creede, and Saguache.

Highway transportation in the Valley includes U.S. Highway 285, traversing the Valley from north to south, and U.S. Highway 160, which connects the Valley with Interstate 25 to the east. Rail service to many communities in the region is provided by the Denver and Rio Grande Western Railroad. Alamosa is served by a commercial airline with daily flights to Denver and New Mexico cities.